The Swiss squandered seven set points in the opener and although he took the second on a tiebreak he capitulated in the decider after dropping serve at 1-2, losing 7-5, 6-7(3), 6-1.
Former US Open champion Del Potro fired down 11 aces and did not face a break point during the one hour, 33 minutes match.
Halep through but Stephens exits in Cincinnati
Greek tyro Stefanos Tsitsipas' dream run at the Rogers Cup continued on Friday as the teenager toppled defending champion Alexander Zverev 3-6, 7-6(11), 6-4 to reach the semi-finals in Toronto.
Defending champion Donna Vekic, of Croatia, earned a hard-fought win over British wild card Gabriella Taylor 7-5, 5-7, 7-6(3).
Top seed Serena Williams made short work of Kazakhstan's Zarina Diyas in the third round of the BNP Paribas Open.
A summary of sports events and sports persons, who made news on Wednesday.
Canada beat USA to enter quarters, Argentina overpower Chile in opening tie
Summary of sports events and persons who made news on Monday
Polish fifth seed Agnieszka Radwanska was the highest women's casualty at the Miami Open on Saturday, blown away for the second time this year by Croatian Mirjana Lucic-Baroni.
Two-times champion Rafa Nadal crashed out in the second round of Wimbledon on Thursday after being out-muscled and out-thought in four sets by an inspired Dustin Brown of Germany.
Six-time champion Novak Djokovic's hopes of turning around his season at the Miami Open ended in the second round when he was defeated 6-3, 6-4 by Frenchman Benoit Paire.
A summary of sports events and sports persons, who made news on Friday.
World number one Simona Halep swatted aside American Nicole Gibbs while Maria Sharapova was flawless in her straight sets victory over Romania's Mihaela Buzarnescu in the opening round of the Shenzhen Open on Monday.
Rafael Nadal was made to wait before his second-round Rogers Cup match due to several rain delays but did his part to put the schedule back on track with a speedy 6-2 6-3 win over Frenchman Benoit Paire on Wednesday.
A misfiring Rafael Nadal had trouble hitting the mark but the third seeded Spaniard still had enough to beat American Donald Young 6-4, 6-2 on Tuesday and advance to the fourth round of the BNP Paribas Open.
Milos Raonic overcame third seed Grigor Dimitrov 7-5, 3-6, 6-3 to reach the third round at the Madrid Open on Tuesday and set up an all-Canadian clash with teenager Denis Shapovalov.
Images from Day 4 of the French Open matches played at Roland Garros in Paris on Wednesday
Former World No 1 Ana Ivanovic was upset 7-5, 6-4 by 42nd-ranked Karolina Pliskova of the Czech Republic in the second round of the US Open on Thursday.
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